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Melatrans brightening cream contains tranexamic acid plus green pea extracts (Pisum sativum) as well as extracts of carica papaya, guava (Psidium guajava) and saxifragaceae. This cream is effective in topical treatment of melasma and reducing various skin dark spots such as sun blemishes and skin aging.

 

Melasma is a prevailing chronic problem, especially in people with darker skin in form of hyperpigmented macules and patches on areas exposed to sunlight, and mostly on the face. Several scientific and clinical studies show that tranexamic acid, pea extract (Pisum sativum) and flower extracts of carica papaya, guava (Psidium guajava) and saxifragaceae are effective in reducing skin pigmentation topically.

:Melatrans Brightening Cream Ingredients

Tranexamic acid, as inhibitor of plasmin, has been very effective in treating melasma. The mechanism of tranexamic acid is unclear, but it is believed that by inhibiting the plasminogen conversion to plasmin, the fibroblasts and prostaglandins growth factor is reduced, thereby inhibits the interaction of melanocytes and keratinocytes, and further inhibits melanin synthesis and melanin accumulation in the skin.

 

By regulating the process of melanogenesis through inhibiting PMEL-17 gene expression and inactivating the enzyme tyrosinase (which plays a major role in skin blemishes), sucrose lauret complex and pea extract (Pisum sativum) inhibit melanosome maturation and melanin. In addition to brightening for a radiant skin, this effective substance also reduces the dark spots caused by aging skin.

 

Carica papaya, Psidium guajava and saxifragaceae flower extracts have the ability to inhibit melanin synthesis by up to 90%, leading to the lightened skin.

:Directions

 

Wash your hands before applying a sufficient amount of Melatrans cream on the affected area, twice a day for 12 weeks.

 

Patch Test: Before using the first dose, apply some cream on a small part of the skin of the arm or behind the eardrum; if no irritation is seen after 24 hours, apply the cream according to the instructions.

Melatrance cream is also effective for brightening and removing stains on hands, feet, elbows, scars, burns, and stains resulting from the aging process. No study has been done to lighten and remove the darkness of the bikini, genitals and armpits, but it is not ineffective and should be used in consultation with a doctor.

Januluma is a medicated cream and its use should be done with a doctor’s prescription. It is possible to use Januluma cream and Melatrance lightening cream at the same time with the doctor’s advice, and in some treatment methods, Melatrance lightening cream is used as a maintenance treatment after stopping the use of Januluma.

To treat melasma and prevent skin darkening, sunscreen with SPF higher than 30 and with sufficient protection against UVA should be used. Using sunscreen is one of the essential aspects of melasma treatment.

During the treatment of melasma and spots, exposure to sunlight, sun lamps, ultraviolet light, and tanning of the treated area should be avoided. Patients who are constantly exposed to sunlight due to work conditions should use sunscreen and protective covering (such as a hat).

Clean the affected area with a tissue and rinse the residue with good water. Do not try to remove the cream with your tongue or by swallowing.

Accidental contact of Melatrance lightening cream with eyes causes inflammation and moderate itching. After contact with the eyes, do not rub the eyes and immediately wash the eyes with plenty of water for at least 15 minutes. While washing, open and close the eyes several times to ensure sufficient washing. See a doctor if eye inflammation persists.

If the cream is swallowed by the patient, a large amount of water or milk should be fed to him immediately to dilute the amount of active ingredients. Then go to the hospital immediately. Do not induce vomiting in any way.